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Target
Calcium/calmodulin-dependent protein kinase kinase 2
Ligand
BDBM92455
Substrate
n/a
Meas. Tech.
ChEMBL_473615 (CHEMBL940168)
IC50
127±n/a nM
Citation
 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A 104:20523-8 (2007) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase kinase 2
Synonyms:
CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64746.61
Organism:
Homo sapiens (Human)
Description:
gi_27437015
Residue:
588
Sequence:
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
  
Inhibitor
Name:
BDBM92455
Synonyms:
CHEMBL265470 | STO-609
Type:
Small organic molecule
Emp. Form.:
C19H10N2O3
Mol. Mass.:
314.2943
SMILES:
OC(=O)c1ccc2c3nc4ccccc4n3c(=O)c3cccc1c23
Structure:
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