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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50375692
Substrate
n/a
Meas. Tech.
ChEMBL_473903 (CHEMBL950179)
IC50
4±n/a nM
Citation
 La, DS; Belzile, J; Bready, JV; Coxon, A; DeMelfi, T; Doerr, N; Estrada, J; Flynn, JC; Flynn, SR; Graceffa, RF; Harriman, SP; Larrow, JF; Long, AM; Martin, MW; Morrison, MJ; Patel, VF; Roveto, PM; Wang, L; Weiss, MM; Whittington, DA; Teffera, Y; Zhao, Z; Polverino, AJ; Harmange, JC Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis. J Med Chem 51:1695-705 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50375692
Synonyms:
CHEMBL272878
Type:
Small organic molecule
Emp. Form.:
C26H22ClN3O5
Mol. Mass.:
491.923
SMILES:
COc1cc2nccc(Oc3ccc4N(CCOc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Structure:
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