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Target
Thymidine kinase
Ligand
BDBM50210804
Substrate
n/a
Meas. Tech.
ChEMBL_474153 (CHEMBL938411)
IC50
84400±n/a nM
Citation
 Focher, F; Lossani, A; Verri, A; Spadari, S; Maioli, A; Gambino, JJ; Wright, GE; Eberle, R; Black, DH; Medveczky, P; Medveczky, M; Shugar, D Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother 51:2028-34 (2007) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
40204.56
Organism:
Macacine herpesvirus 1
Description:
ChEMBL_474153
Residue:
370
Sequence:
MASHAGHQDSPALDRVAGSAGHGDHPSALLRIYVDGPHGLGKTTTAAALAAALGRRDEIEYVPEPMAYWQTLGGPQTITRIFDAQHRLDRGEISASEAAMAMASAQVTMSTPYAVTESAVAPHIGAELPPGHGPHPNIDLTLVFDRHPVASLLCYPAARYLMGSLSLPTVLSFAALLPQTTPGTNLVLGALPEAVHAERLAQRQRPGERLDLAMLSAIRRVYDMLGNAIVYLQRGGSWRADWRRLSPARSAAASGRPARILPRPEIEDTIFALFCAPELLDETGEPYRVFAWTLDLLAERLRPMHLLVLDYNQAPHHCWMDLMEMIPEMTPTLPATPGSMLTLQLLAREFAREMTSTRGGDVGGEGRETR
  
Inhibitor
Name:
BDBM50210804
Synonyms:
2-Amino-9-(4-hydroxy-3-hydroxymethyl-butyl)-1,9-dihydro-purin-6-one | 2-Amino-9-(4-hydroxy-3-hydroxymethyl-butyl)-1,9-dihydro-purin-6-one (PCV) | 2-Amino-9-(4-hydroxy-3-hydroxymethyl-butyl)-1,9-dihydro-purin-6-one(PCV, Penciclovir) | 2-[2-(2-Amino-6-hydroxy-purin-9-yl)-ethyl]-propane-1,3-diol | 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE | BRL-39123 | CHEMBL1540 | PENCICLOVIR | pencyclovir
Type:
Small organic molecule
Emp. Form.:
C10H15N5O3
Mol. Mass.:
253.2578
SMILES:
Nc1nc2n(CCC(CO)CO)cnc2c(=O)[nH]1
Structure:
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