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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM16224
Substrate
n/a
Meas. Tech.
ChEMBL_475113 (CHEMBL932635)
IC50
6900±n/a nM
Citation
 Caldwell, JJ; Davies, TG; Donald, A; McHardy, T; Rowlands, MG; Aherne, GW; Hunter, LK; Taylor, K; Ruddle, R; Raynaud, FI; Verdonk, M; Workman, P; Garrett, MD; Collins, I Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem 51:2147-57 (2008) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM16224
Synonyms:
6-phenylpurine compound 6 | N-methyl-1-[4-(9H-purin-6-yl)phenyl]methanamine | methyl({[4-(9H-purin-6-yl)phenyl]methyl})amine
Type:
Small organic molecule
Emp. Form.:
C13H13N5
Mol. Mass.:
239.2758
SMILES:
CNCc1ccc(cc1)-c1ncnc2nc[nH]c12
Structure:
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