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Target
Polyphenol oxidase 2
Ligand
BDBM50236967
Substrate
n/a
Meas. Tech.
ChEMBL_475650 (CHEMBL940777)
IC50
540±n/a nM
Citation
 Liu, J; Yi, W; Wan, Y; Ma, L; Song, H 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem 16:1096-102 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50236967
Synonyms:
1-(4-(4-Hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide | 1-(4-(4-hydroxyphenyl)butan-2-ylidene)thiosemicarbazide | CHEMBL272958
Type:
Small organic molecule
Emp. Form.:
C11H15N3OS
Mol. Mass.:
237.321
SMILES:
CC(CCc1ccc(O)cc1)=NNC(N)=S |w:11.12|
Structure:
Search PDB for entries with ligand similarity: