Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50376590
Substrate
n/a
Meas. Tech.
ChEMBL_477429 (CHEMBL929415)
EC50
67±n/a nM
Citation
 Varoli, L; Andreani, A; Burnelli, S; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Bedini, A; Fazio, N; Spampinato, S Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett 18:2972-6 (2008) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50376590
Synonyms:
CHEMBL402207
Type:
Small organic molecule
Emp. Form.:
C44H58N2O2
Mol. Mass.:
646.9424
SMILES:
C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(CC1)C1CC[N+](C)(CCCC(O)(c2ccccc2)c2ccccc2)CC1 |(6.92,-12.95,;7.69,-11.62,;6.35,-10.87,;6.33,-9.33,;4.99,-8.57,;4.97,-7.03,;4.94,-5.48,;6.5,-7,;7.3,-8.33,;8.83,-8.3,;9.58,-6.95,;8.78,-5.63,;7.25,-5.66,;3.44,-7.08,;2.63,-5.77,;1.1,-5.81,;.36,-7.17,;1.18,-8.48,;2.71,-8.43,;8.45,-12.95,;9.99,-12.97,;10.77,-11.64,;10.01,-10.29,;8.47,-10.29,;12.31,-11.65,;13.06,-12.99,;14.6,-13,;15.38,-11.68,;16.47,-10.58,;16.69,-12.49,;16.64,-14.03,;17.95,-14.84,;17.9,-16.38,;17.86,-17.91,;16.36,-16.34,;15.63,-14.98,;14.09,-14.94,;13.28,-16.25,;14.02,-17.61,;15.56,-17.65,;19.43,-16.44,;20.16,-17.8,;21.69,-17.85,;22.51,-16.55,;21.78,-15.18,;20.25,-15.13,;14.62,-10.33,;13.08,-10.32,)|
Structure:
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