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Target
Aurora kinase B
Ligand
BDBM31093
Substrate
n/a
Meas. Tech.
ChEMBL_477961 (CHEMBL927030)
IC50
172±n/a nM
Citation
 Manfredi, MG; Ecsedy, JA; Meetze, KA; Balani, SK; Burenkova, O; Chen, W; Galvin, KM; Hoar, KM; Huck, JJ; LeRoy, PJ; Ray, ET; Sells, TB; Stringer, B; Stroud, SG; Vos, TJ; Weatherhead, GS; Wysong, DR; Zhang, M; Bolen, JB; Claiborne, CF Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A 104:4106-11 (2007) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AURKB_MOUSE | Aik2 | Aim1 | Airk2 | Ark2 | Aurkb | Serine/threonine-protein kinase 12 | Stk1 | Stk12 | Stk5
Type:
PROTEIN
Mol. Mass.:
39401.97
Organism:
Mus musculus
Description:
ChEMBL_1339463
Residue:
345
Sequence:
MAQKENAYPWPYGSKTSQSGLNTLSQRVLRKEPATTSALALVNRFNSQSTAAPGQKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRANSRRVLPPSAL
  
Inhibitor
Name:
BDBM31093
Synonyms:
4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | CHEMBL259084 | MLN-8054 | cid_11712649
Type:
Small organic molecule
Emp. Form.:
C25H15ClF2N4O2
Mol. Mass.:
476.862
SMILES:
OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13|
Structure:
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