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Target
Type-1 angiotensin II receptor
Ligand
BDBM50376928
Substrate
n/a
Meas. Tech.
ChEMBL_478823 (CHEMBL925710)
Kd
10.47±n/a nM
Citation
 Cappelli, A; Nannicini, C; Gallelli, A; Giuliani, G; Valenti, S; Mohr, Gl; Anzini, M; Mennuni, L; Ferrari, F; Caselli, G; Giordani, A; Peris, W; Makovec, F; Giorgi, G; Vomero, S Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. J Med Chem 51:2137-46 (2008) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50376928
Synonyms:
CHEMBL259114
Type:
Small organic molecule
Emp. Form.:
C24H23N7O
Mol. Mass.:
425.4857
SMILES:
CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O
Structure:
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