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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50412008
Substrate
n/a
Meas. Tech.
ChEMBL_478938 (CHEMBL936364)
IC50
4.79±n/a nM
Citation
 Zhu, Z; Buolamwini, JK Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem 16:3848-65 (2008) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50412008
Synonyms:
CHEMBL259866
Type:
Small organic molecule
Emp. Form.:
C17H17N5O6S
Mol. Mass.:
419.412
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(CSc3cccc(c3)[N+]([O-])=O)ncnc12
Structure:
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