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TargetAlpha-1A adrenergic receptor
LigandBDBM50118705
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479649
EC50 9±n/a nM
Citation Whitlock, GAConlon, KMcMurray, GRoberts, LRStobie, AThurlow, RJ Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists. Bioorg Med Chem Lett18:2930-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-1A adrenergic receptor
Name:Alpha adrenergic receptor (1a and 1d)
Synonyms:ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:Cell-surface receptors
Mol. Mass.:51511.67
Organism:Homo sapiens (Human)
Description:P35348
Residue:466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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  Blast E-value cutoff:
BDBM50118705
NameBDBM50118705
Synonyms:ABT-866 | CHEMBL326702 | Ethanesulfonic acid [3-(1H-imidazol-4-ylmethyl)-phenyl]-amide | N-(3-((1H-imidazol-4-yl)methyl)phenyl)ethanesulfonamide | N-[3-(1H-imidazol-4-ylmethyl)-phenyl]ethanesulfonamide
TypeSmall organic molecule
Emp. Form.C12H15N3O2S
Mol. Mass.265.331
SMILESCCS(=O)(=O)Nc1cccc(Cc2cnc[nH]2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a