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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50377402
Substrate
n/a
Meas. Tech.
ChEMBL_479655 (CHEMBL922403)
EC50
4580±n/a nM
Citation
 Whitlock, GA; Conlon, K; McMurray, G; Roberts, LR; Stobie, A; Thurlow, RJ Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists. Bioorg Med Chem Lett 18:2930-4 (2008) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
450
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50377402
Synonyms:
CHEMBL260576
Type:
Small organic molecule
Emp. Form.:
C17H15N3
Mol. Mass.:
261.3211
SMILES:
C1Cc2c(cccc2-c2cccnc2)C1c1ncc[nH]1 |w:14.17|
Structure:
Search PDB for entries with ligand similarity: