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TargetPhospholipase A2, membrane associated
LigandBDBM50259951
Substrate/Competitorn/a
Meas. Tech.ChEMBL_549471
IC50 90700±n/a nM
Citation De Rosa, SCrispino, ADe Giulio, AIodice, CBenrezzouk, RTerencio, MCFerrándiz, MLAlcaraz, MJPayá, M A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. J Nat Prod61:931-5 (1998) [PubMed]  Article
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Phospholipase A2, membrane associated
Name:Phospholipase A2 group IIA
Synonyms:GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | Phosphatidylcholine 2-acylhydrolase
Type:Hydrolase
Mol. Mass.:16101.20
Organism:Homo sapiens (human)
Description:The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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BDBM50259951
NameBDBM50259951
Synonyms:CHEMBL480681 | cacospongionolide
TypeSmall organic molecule
Emp. Form.C25H36O4
Mol. Mass.400.5509
SMILESC[C@H]1CC[C@@]23C[C@]2(C)CCC[C@@H]3[C@@]1(C)CCC1=CC[C@@H](OC1)C1=CC(=O)O[C@H]1O |r,t:19,26|
Structure
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