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TargetPhospholipase A2, membrane associated
LigandBDBM50250399
Substrate/Competitorn/a
Meas. Tech.ChEMBL_549471
IC50 93200±n/a nM
Citation De Rosa, SCrispino, ADe Giulio, AIodice, CBenrezzouk, RTerencio, MCFerrándiz, MLAlcaraz, MJPayá, M A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. J Nat Prod61:931-5 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phospholipase A2, membrane associated
Name:Phospholipase A2 group IIA
Synonyms:GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | Phosphatidylcholine 2-acylhydrolase
Type:Hydrolase
Mol. Mass.:16101.20
Organism:Homo sapiens (human)
Description:The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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BDBM50250399
NameBDBM50250399
Synonyms:5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one | 5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one | CHEMBL463914 | manoalide
TypeSmall organic molecule
Emp. Form.C25H36O5
Mol. Mass.416.5503
SMILESC\C(CCC1=C(C)CCCC1(C)C)=C/CCC1=CC[C@@H](O[C@H]1O)C1=CC(=O)O[C@H]1O |r,c:4,t:17,25|
Structure
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