Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50260720
Substrate
n/a
Meas. Tech.
ChEMBL_556337 (CHEMBL954070)
Ki
2.84±n/a nM
Citation
 Wustrow, DJ; Maynard, GD; Yuan, J; Zhao, H; Mao, J; Guo, Q; Kershaw, M; Hammer, J; Brodbeck, RM; Near, KE; Zhou, D; Beers, DS; Chenard, BL; Krause, JE; Hutchison, AJ Aminopyrazine CB1 receptor inverse agonists. Bioorg Med Chem Lett 18:3376-81 (2008) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50260720
Synonyms:
1-(5,6-bis(4-ethoxyphenyl)pyrazin-2-yl)-4-(ethylamino)piperidine-4-carboxamide | CHEMBL495892
Type:
Small organic molecule
Emp. Form.:
C28H35N5O3
Mol. Mass.:
489.6092
SMILES:
CCNC1(CCN(CC1)c1cnc(-c2ccc(OCC)cc2)c(n1)-c1ccc(OCC)cc1)C(N)=O
Structure:
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