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Target
Neutrophil elastase
Ligand
BDBM50269858
Substrate
n/a
Meas. Tech.
ChEMBL_508157 (CHEMBL1008215)
IC50
5490±n/a nM
Citation
 Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 282:20836-46 (2007) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
ELNE_MOUSE | Ela2 | Elane
Type:
PROTEIN
Mol. Mass.:
28661.19
Organism:
Mus musculus
Description:
ChEMBL_1463437
Residue:
265
Sequence:
MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIARNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVIIQLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFADWINSIIRSHNDHLLTHPKDREGRTN
  
Inhibitor
Name:
BDBM50269858
Synonyms:
Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-cyclopropylcarbamoyl)-2-(2-fluoro-phenyl)-ethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C19H19FN3O
Mol. Mass.:
324.3715
SMILES:
[NH3+][C@@H](Cc1ccccc1F)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N |r|
Structure:
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