Target
Neutrophil elastase
Ligand
BDBM50052693
Substrate
n/a
Meas. Tech.
ChEMBL_508157 (CHEMBL1008215)
IC50
>10000±n/a nM
Citation
 Méthot, NRubin, JGuay, DBeaulieu, CEthier, DReddy, TJRiendeau, DPercival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 282:20836-46 (2007) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
ELNE_MOUSE | Ela2 | Elane
Type:
PROTEIN
Mol. Mass.:
28661.19
Organism:
Mus musculus
Description:
ChEMBL_1463437
Residue:
265
Sequence:
MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIARNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVIIQLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFADWINSIIRSHNDHLLTHPKDREGRTN
  
Inhibitor
Name:
BDBM50052693
Synonyms:
(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester | (2S,3S)-ethyl 3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate | (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester | 3-[3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester | Aloxistatin | CHEMBL63440
Type:
Small organic molecule
Emp. Form.:
C17H30N2O5
Mol. Mass.:
342.4305
SMILES:
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |r|
Structure:
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