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Target
Substance-P receptor
Ligand
BDBM50140771
Substrate
n/a
Meas. Tech.
ChEMBL_528534 (CHEMBL972069)
EC50
24.4±n/a nM
Citation
 Gafner, S; Dietz, BM; McPhail, KL; Scott, IM; Glinski, JA; Russell, FE; McCollom, MM; Budzinski, JW; Foster, BC; Bergeron, C; Rhyu, MR; Bolton, JL Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod 69:432-5 (2006) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50140771
Synonyms:
((2R,3R)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-(2-iodo-benzyl)-amine | (cis)-N-(2-iodobenzyl)-2-benzhydrylquinuclidin-3-amine | CHEMBL24999 | L-703606
Type:
Small organic molecule
Emp. Form.:
C27H29IN2
Mol. Mass.:
508.437
SMILES:
Ic1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 |r,wU:9.9,16.19,TLB:17:16:12.11:14.15,THB:8:9:12.11:14.15,(23.35,-28.77,;24.59,-29.47,;25.82,-28.74,;27.08,-29.44,;27.09,-30.88,;25.86,-31.6,;24.61,-30.89,;23.38,-31.62,;23.39,-33.05,;22.16,-33.77,;20.81,-33.16,;19.33,-33.8,;19.53,-35.19,;21.07,-34.54,;21.32,-32.62,;20.87,-31.51,;22.44,-35.17,;23.21,-36.5,;24.75,-36.5,;25.52,-37.85,;27.07,-37.85,;27.84,-36.5,;27.07,-35.16,;25.52,-35.17,;22.43,-37.84,;20.88,-37.84,;20.11,-39.17,;20.88,-40.52,;22.44,-40.51,;23.21,-39.17,)|
Structure:
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