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Target
Sex hormone-binding globulin
Ligand
BDBM50240916
Substrate
n/a
Meas. Tech.
ChEMBL_547404 (CHEMBL1025921)
IC50
2600±n/a nM
Citation
 Schöttner, M; Spiteller, G; Gansser, D Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin. J Nat Prod 61:119-21 (1998) [PubMed]  Article 
Target
Name:
Sex hormone-binding globulin
Synonyms:
SHBG | SHBG_HUMAN | Testis-specific androgen-binding protein
Type:
PROTEIN
Mol. Mass.:
43780.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_466706
Residue:
402
Sequence:
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
  
Inhibitor
Name:
BDBM50240916
Synonyms:
(-)-3,4-divanillyltetrahydrofuran | (3R,4R)-3,4-Bis(4-hydroxy-3-methoxybenzyl)tetrahydrofuran | 4-[4-(4-hydroxy-3-methoxybenzyl)-(3R,4R)-tetrahydro-3-furanylmethyl]-2-methoxyphenol | CHEMBL367448
Type:
Small organic molecule
Emp. Form.:
C20H24O5
Mol. Mass.:
344.4016
SMILES:
COc1cc(C[C@H]2COC[C@@H]2Cc2ccc(O)c(OC)c2)ccc1O |r|
Structure:
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