Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetExcitatory amino acid transporter 2
LigandBDBM50252049
Substrate/Competitorn/a
Meas. Tech.ChEMBL_487937
Ki>3000000±n/a nM
Citation Sagot, EJensen, AAPickering, DSPu, XUmberti, MStensbøl, TBNielsen, BAssaf, ZAboab, BBolte, JGefflaut, TBunch, L Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. J Med Chem51:4085-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Excitatory amino acid transporter 2
Name:Excitatory amino acid transporter 2
Synonyms:EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2
Type:Enzyme Catalytic Domain
Mol. Mass.:62103.57
Organism:Homo sapiens (Human)
Description:Excitatory Amino Acid EAAT2 0 0::P43004
Residue:574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50252049
NameBDBM50252049
Synonyms:(1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | (2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid | CHEMBL482081
TypeSmall organic molecule
Emp. Form.C8H13NO6
Mol. Mass.219.1919
SMILESN[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a