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Target
Ectonucleoside triphosphate diphosphohydrolase 1
Ligand
BDBM50262422
Substrate
n/a
Meas. Tech.
ChEMBL_514528 (CHEMBL968882)
Ki
46000±n/a nM
Citation
 Brunschweiger, A; Iqbal, J; Umbach, F; Scheiff, AB; Munkonda, MN; Sévigny, J; Knowles, AF; Müller, CE Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem 51:4518-28 (2008) [PubMed]  Article 
Target
Name:
Ectonucleoside triphosphate diphosphohydrolase 1
Synonyms:
ATPDase | CD_antigen=CD39 | Cd39 | ENTP1_RAT | Ecto-ATP diphosphohydrolase | Ecto-apyrase | Entpd1 | Lymphoid cell activation antigen | NTPDase 1
Type:
PROTEIN
Mol. Mass.:
57412.31
Organism:
Rattus norvegicus
Description:
ChEMBL_463990
Residue:
511
Sequence:
MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
  
Inhibitor
Name:
BDBM50262422
Synonyms:
CHEMBL477339 | sodium (E)-4-((3-formyl-4-hydroxy-5-methyl-2-(phosphonatooxymethyl)phenyl)diazenyl)benzene-1,3-disulfonate
Type:
Small organic molecule
Emp. Form.:
C15H11N2O12PS2
Mol. Mass.:
506.36
SMILES:
Cc1cc(N=Nc2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O |w:4.3|
Structure:
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