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Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50048403
Substrate
n/a
Meas. Tech.
ChEMBL_535544 (CHEMBL986170)
IC50
1300±n/a nM
Citation
 Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett 18:5316-9 (2008) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
K3 | KCNN3 | KCNN3_HUMAN | Small conductance calcium-activated potassium channel protein 3 | Small conductance calcium-activated potassium channel protein 3 (KCa2.3)
Type:
Protein
Mol. Mass.:
82053.75
Organism:
Homo sapiens (Human)
Description:
Q9UGI6
Residue:
731
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
  
Inhibitor
Name:
BDBM50048403
Synonyms:
1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methylquinolinium) Diiodide Hydrate | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride ; Dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(Deq) | 1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(dequalinium) | CHEMBL121663 | DQ+ | Dequalinium chloride | Dequqlinium | GNF-Pf-5483 | dequalinium
Type:
Small organic molecule
Emp. Form.:
C30H40N4
Mol. Mass.:
456.6643
SMILES:
Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12
Structure:
Search PDB for entries with ligand similarity: