Reaction Details Report a problem with these data
Target
Thrombopoietin receptor
Ligand
BDBM50263333
Substrate
n/a
Meas. Tech.
ChEMBL_535587 (CHEMBL987061)
EC50
67±n/a nM
Citation
 Alper, PB; Marsilje, TH; Mutnick, D; Lu, W; Chatterjee, A; Roberts, MJ; He, Y; Karanewsky, DS; Chow, D; Lao, J; Gerken, A; Tuntland, T; Liu, B; Chang, J; Gordon, P; Seidel, HM; Tian, SS Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Bioorg Med Chem Lett 18:5255-8 (2008) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50263333
Synonyms:
9-(3,5-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid | CHEMBL477175
Type:
Small organic molecule
Emp. Form.:
C25H21NO3
Mol. Mass.:
383.4391
SMILES:
Cc1cc(C)cc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Structure:
Search PDB for entries with ligand similarity: