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Targetβ-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH)
LigandBDBM50245928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_559691
IC50 1.99±n/a nM
Citation Alhamadsheh, MMWaters, NCSachdeva, SLee, PReynolds, KA Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett18:6402-5 (2008) [PubMed]  Article
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β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH)
Name:β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH)
Synonyms:3-oxoacyl-[acyl-carrier-protein] synthase III
Type:Enzyme
Mol. Mass.:34865.07
Organism:Mycobacterium tuberculosis
Description:P9WNG3
Residue:335
Sequence:
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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BDBM50245928
NameBDBM50245928
Synonyms:2-tosylnaphthalene-1,4-dione | CHEMBL454282
TypeSmall organic molecule
Emp. Form.C17H12O4S
Mol. Mass.312.34
SMILESCc1ccc(cc1)S(=O)(=O)C1=CC(=O)c2ccccc2C1=O |t:11|
Structure
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n/a
NameBDBM50245928
Synonyms:2-tosylnaphthalene-1,4-dione | CHEMBL454282
TypeSmall organic molecule
Emp. Form.C17H12O4S
Mol. Mass.312.34
SMILESCc1ccc(cc1)S(=O)(=O)C1=CC(=O)c2ccccc2C1=O |t:11|
Structure
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