Target
Delta-type opioid receptor
Ligand
BDBM50252925
Substrate
n/a
Meas. Tech.
ChEMBL_534603 (CHEMBL989028)
EC50
89±n/a nM
Citation
 Le Bourdonnec, BWindh, RTAjello, CWLeister, LKGu, MChu, GHTuthill, PABarker, WMKoblish, MWiant, DDGraczyk, TMBelanger, SCassel, JAFeschenko, MSBrogdon, BLSmith, SAChrist, DDDerelanko, MJKutz, SLittle, PJDeHaven, RNDeHaven-Hudkins, DLDolle, RE Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). J Med Chem 51:5893-6 (2008) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50252925
Synonyms:
CHEMBL494275 | N,N-Diethyl-4-(1'-methylspiro[chromene-2,4'-piperidine]-4-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C25H30N2O2
Mol. Mass.:
390.5179
SMILES:
CCN(CC)C(=O)c1ccc(cc1)C1=CC2(CCN(C)CC2)Oc2ccccc12 |t:14|
Structure:
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