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Target
Glutamate receptor 4
Ligand
BDBM50002369
Substrate
n/a
Meas. Tech.
ChEMBL_539474 (CHEMBL1028970)
Ki
3570±n/a nM
Citation
 Butini, S; Pickering, DS; Morelli, E; Coccone, SS; Trotta, F; De Angelis, M; Guarino, E; Fiorini, I; Campiani, G; Novellino, E; Schousboe, A; Christensen, JK; Gemma, S 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. J Med Chem 51:6614-8 (2008) [PubMed]  Article 
Target
Name:
Glutamate receptor 4
Synonyms:
GRIA4_RAT | Glur4 | Glutamate receptor ionotropic, AMPA 4 | Glutamate receptors NMDA/AMPA | Gria4
Type:
PROTEIN
Mol. Mass.:
100766.57
Organism:
Rattus norvegicus
Description:
ChEMBL_539474
Residue:
902
Sequence:
MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEATRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
  
Inhibitor
Name:
BDBM50002369
Synonyms:
(2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid | (3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline | CHEMBL275040 | Digenin | Digensaeure | Helminal | Kainate | Kainsaeure | L-alpha-kainic acid | alpha-Kainic acid | digenic acid | kainic acid
Type:
Small organic molecule
Emp. Form.:
C10H15NO4
Mol. Mass.:
213.2304
SMILES:
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: