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Target
Glutamate receptor 3
Ligand
BDBM50252920
Substrate
n/a
Meas. Tech.
ChEMBL_539482 (CHEMBL1029767)
EC50
33900±n/a nM
Citation
 Butini, S; Pickering, DS; Morelli, E; Coccone, SS; Trotta, F; De Angelis, M; Guarino, E; Fiorini, I; Campiani, G; Novellino, E; Schousboe, A; Christensen, JK; Gemma, S 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. J Med Chem 51:6614-8 (2008) [PubMed]  Article 
Target
Name:
Glutamate receptor 3
Synonyms:
GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100383.57
Organism:
RAT
Description:
Glutamate-AMPA GRIA3 RAT::P19492
Residue:
888
Sequence:
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
  
Inhibitor
Name:
BDBM50252920
Synonyms:
(S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione | CHEMBL492469
Type:
Small organic molecule
Emp. Form.:
C9H11N3O4S
Mol. Mass.:
257.266
SMILES:
N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O |r|
Structure:
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