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TargetCarbonic anhydrase 12
LigandBDBM50155556
Substrate/Competitorn/a
Meas. Tech.ChEMBL_544669
Ki 0.39±n/a nM
Citation Thiry, ARolin, SVullo, DFrankart, AScozzafava, ADogné, JMWouters, JSupuran, CTMasereel, B Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem43:2853-60 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase
Synonyms:CA-XII | Carbonate dehydratase XII | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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  Blast E-value cutoff:
BDBM50155556
NameBDBM50155556
Synonyms:2,3-dihydro-1H-indene-5-sulfonamide | CHEMBL364869 | Indan-5-sulfonic acid amide | indane-5-sulfonamide
TypeSmall organic molecule
Emp. Form.C9H11NO2S
Mol. Mass.197.254
SMILESNS(=O)(=O)c1ccc2CCCc2c1
Structure
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n/a