Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50258653
Substrate
n/a
Meas. Tech.
ChEMBL_523689 (CHEMBL998034)
Ki
9±n/a nM
Citation
 Manera, C; Saccomanni, G; Adinolfi, B; Benetti, V; Ligresti, A; Cascio, MG; Tuccinardi, T; Lucchesi, V; Martinelli, A; Nieri, P; Masini, E; Di Marzo, V; Ferrarini, PL Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. J Med Chem 52:3644-51 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50258653
Synonyms:
CHEMBL512063 | trans-N-(4-Methylcyclohexyl)-1-(p-fluorobenzyl)-1,8-naphthyridin-2(1H)-on-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H24FN3O2
Mol. Mass.:
393.454
SMILES:
C[C@H]1CC[C@@H](CC1)NC(=O)c1cc2cccnc2n(Cc2ccc(F)cc2)c1=O |r,wU:4.7,wD:1.0,(18.09,5.74,;16.75,4.97,;15.42,5.74,;14.08,4.97,;14.08,3.44,;15.42,2.67,;16.75,3.43,;12.75,2.67,;11.42,3.44,;11.41,4.98,;10.09,2.66,;8.73,3.44,;7.4,2.65,;6.06,3.42,;4.73,2.64,;4.73,1.1,;6.07,.33,;7.4,1.1,;8.75,.33,;8.75,-1.21,;10.09,-1.97,;10.09,-3.5,;11.42,-4.27,;12.75,-3.49,;14.09,-4.25,;12.74,-1.96,;11.42,-1.2,;10.09,1.11,;11.43,.34,)|
Structure:
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