Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50258572
Substrate
n/a
Meas. Tech.
ChEMBL_523689 (CHEMBL998034)
Ki
22±n/a nM
Citation
 Manera, C; Saccomanni, G; Adinolfi, B; Benetti, V; Ligresti, A; Cascio, MG; Tuccinardi, T; Lucchesi, V; Martinelli, A; Nieri, P; Masini, E; Di Marzo, V; Ferrarini, PL Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. J Med Chem 52:3644-51 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50258572
Synonyms:
CHEMBL511253 | N-Cycloheptyl-1-benzyl-1,8-naphthyridin-2(1H)-on-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H25N3O2
Mol. Mass.:
375.4635
SMILES:
O=C(NC1CCCCCC1)c1cc2cccnc2n(Cc2ccccc2)c1=O
Structure:
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