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TargetMelanocortin receptor 4
LigandBDBM50268805
Substrate/Competitorn/a
Meas. Tech.ChEMBL_523578
EC50 0±n/a nM
Citation Qu, HCai, MMayorov, AVGrieco, PZingsheim, MTrivedi, DHruby, VJ Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. J Med Chem52:3627-35 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50268805
n/a
NameBDBM50268805
Synonyms:Ac-Tyr-Val-Nle-Gly-His-DPhe-trans-Xaa-Trp-Asp-Arg-Phe-Gly-NH2 | CHEMBL510270
TypeSmall organic molecule
Emp. Form.C77H102N22O16
Mol. Mass.1591.7716
SMILESCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O)N=C(N)N |r,wU:8.8,45.46,59.63,96.101,35.35,77.82,wD:4.4,57.117,12.21,63.66,85.90,(3.89,-26.77,;2.57,-27.55,;1.22,-26.79,;-.1,-27.57,;-1.45,-26.81,;-2.78,-27.6,;-2.76,-29.14,;-1.41,-29.89,;-4.09,-29.92,;-4.07,-31.46,;-5.4,-32.25,;-6.73,-31.49,;-5.38,-33.78,;-4.04,-34.54,;-2.72,-33.75,;-2.73,-32.22,;-1.4,-31.43,;-.06,-32.19,;1.27,-31.4,;-.04,-33.74,;-1.37,-34.52,;-6.71,-34.57,;-6.71,-36.11,;-8.02,-36.89,;-5.35,-36.86,;-5.43,-29.17,;-5.44,-27.63,;-6.74,-29.95,;-1.46,-25.28,;-2.8,-24.52,;-.14,-24.49,;-.16,-22.95,;1.17,-22.16,;2.52,-22.92,;1.16,-20.62,;2.48,-19.84,;2.46,-18.3,;1.13,-17.55,;.96,-16.02,;-.56,-15.71,;-1.31,-17.05,;-.27,-18.18,;3.82,-20.6,;3.85,-22.14,;5.15,-19.82,;6.5,-20.57,;6.51,-22.12,;7.85,-22.87,;7.87,-24.42,;9.21,-25.18,;10.53,-24.39,;10.51,-22.85,;9.17,-22.09,;7.86,-19.86,;9.11,-20.76,;7.93,-18.32,;6.9,-17.17,;7.69,-15.84,;9.19,-16.18,;9.34,-17.71,;10.66,-18.5,;10.65,-20.04,;12,-17.74,;13.32,-18.54,;13.31,-20.08,;14.59,-20.94,;16.03,-20.4,;16.98,-21.61,;16.14,-22.89,;16.51,-24.38,;15.41,-25.47,;13.93,-25.05,;13.55,-23.56,;14.65,-22.48,;14.67,-17.78,;14.68,-16.24,;15.99,-18.57,;17.33,-17.82,;17.34,-16.27,;18.68,-15.52,;20.02,-16.29,;18.7,-13.97,;18.66,-18.59,;18.64,-20.14,;20,-17.84,;21.32,-18.63,;21.3,-20.18,;22.62,-20.95,;22.61,-22.5,;23.94,-23.27,;23.91,-24.81,;22.59,-25.56,;25.26,-25.58,;22.66,-17.88,;22.67,-16.34,;23.99,-18.65,;25.33,-17.89,;25.35,-16.35,;26.69,-15.6,;28.02,-16.38,;29.36,-15.63,;29.38,-14.09,;28.05,-13.3,;26.71,-14.06,;26.66,-18.67,;26.64,-20.22,;28,-17.92,;29.32,-18.7,;30.66,-17.95,;31.99,-18.73,;30.68,-16.41,;7.08,-14.43,;7.99,-13.19,;7.38,-11.78,;9.52,-13.37,)|
Structure
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