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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50293664
Substrate
n/a
Meas. Tech.
ChEMBL_571638 (CHEMBL1031293)
IC50
10300±n/a nM
Citation
 Sentürk, M; Talaz, O; Ekinci, D; Cavdar, H; Küfrevioglu, OI In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett 19:3661-3 (2009) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50293664
Synonyms:
9(R(S))-Hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2(R(S)-yl nitrate | CHEMBL556791
Type:
Small organic molecule
Emp. Form.:
C11H11NO4
Mol. Mass.:
221.2093
SMILES:
OC1C2CC(O[N+]([O-])=O)C1c1ccccc21 |TLB:11:10:1:4.3,14:15:1:4.3,5:4:1:15.10|
Structure:
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