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TargetGrb2-SH2
LigandBDBM50124303
Substrate/Competitorn/a
Meas. Tech.ChEMBL_575368
Kd 25000±n/a nM
Citation Jiang, SLiao, CBindu, LYin, BWorthy, KWFisher, RJBurke, TRNicklaus, MCRoller, PP Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg Med Chem Lett19:2693-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Grb2-SH2
Name:Growth factor receptor-bound protein 2
Synonyms:GRB2 | GRB2 adapter protein | Growth factor receptor-bound protein 2
Type:Protein
Mol. Mass.:25205.04
Organism:Homo sapiens (Human)
Description:P62993
Residue:217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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BDBM50124303
NameBDBM50124303
Synonyms:3-[16-carbamoyl-31-carbamoylmethyl-10-(2-carboxyethyl)-4,19-di(4-hydroxybenzyl)-7-isobutyl-28-isopropyl-22-(2-methylsulfanylethyl)-3,6,9,12,18,21,24,27,30,33-decaoxo-14-thia-2,5,8,11,17,20,23,26,29,32-decaazacyclotritriacontanyl]propanoic acid | CHEMBL444114 | cyclo(CH2CO-Glu1-Leu2-Tyr3-Glu4-Asn5-Val6-Gly7-Met8-Tyr9-Cys10)-amide
TypeSmall organic molecule
Emp. Form.C55H78N12O18S2
Mol. Mass.1259.407
SMILESCSCC[C@@H]1NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O)C(C)C
Structure
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