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TargetCyclic AMP-dependent protein kinase (PKA)
LigandBDBM50366348
Substrate/Competitorn/a
Meas. Tech.ChEMBL_586302
Ki 3000±n/a nM
Citation Engh, RAGirod, AKinzel, VHuber, RBossemeyer, D Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem271:26157-64 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclic AMP-dependent protein kinase (PKA)
Name:Cyclic AMP-dependent protein kinase (PKA)
Synonyms:PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit
Type:Enzyme
Mol. Mass.:40766.33
Organism:Oryctolagus cuniculus (Rabbit)
Description:Q95J97
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVML
SKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFF
ADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50366348
NameBDBM50366348
Synonyms:CHEMBL1233654
TypeSmall organic molecule
Emp. Form.C14H17N3O2S
Mol. Mass.291.369
SMILESC[C@H]1CNCCN1S(=O)(=O)c1cccc2cnccc12 |r|
Structure
n/a