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Target
cAMP-dependent protein kinase
Ligand
BDBM15210
Substrate
n/a
Meas. Tech.
ChEMBL_586302 (CHEMBL1060164)
Ki
1200±n/a nM
Citation
 Engh, RA; Girod, A; Kinzel, V; Huber, R; Bossemeyer, D Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem 271:26157-64 (1996) [PubMed]  Article 
Target
Name:
cAMP-dependent protein kinase
Synonyms:
Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit
Type:
Enzyme
Mol. Mass.:
40766.33
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
Q95J97
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVMLSKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFFADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM15210
Synonyms:
CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylaminoethyl)isoquinoline-5-sulfonamide | N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C12H15N3O2S
Mol. Mass.:
265.331
SMILES:
CNCCNS(=O)(=O)c1cccc2cnccc12
Structure:
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