Target
Carbonic anhydrase 12
Ligand
BDBM50299575
Substrate
n/a
Meas. Tech.
ChEMBL_592387 (CHEMBL1036960)
Ki
4710±n/a nM
Citation
 Lopez, MPaul, BHofmann, AMorizzi, JWu, QKCharman, SAInnocenti, AVullo, DSupuran, CTPoulsen, SA S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J Med Chem 52:6421-32 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50299575
Synonyms:
(2S,3S,4S,5R,6S)-2-(methoxycarbonyl)-6-sulfamoyltetrahydro-2H-pyran-3,4,5-triyl triacetate | CHEMBL584312
Type:
Small organic molecule
Emp. Form.:
C13H19NO11S
Mol. Mass.:
397.355
SMILES:
COC(=O)[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)S(N)(=O)=O |r|
Structure:
Search PDB for entries with ligand similarity: