Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 10
Ligand
BDBM50301103
Substrate
n/a
Meas. Tech.
ChEMBL_598554 (CHEMBL1043546)
IC50
17±n/a nM
Citation
Li, YL; Shi, E; Burns, D; Li, Y; Covington, MB; Pan, M; Scherle, P; Friedman, S; Metcalf, B; Yao, W Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety. Bioorg Med Chem Lett 19:5037-42 (2009) [PubMed] Article
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:
ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:
Enzyme
Mol. Mass.:
84160.93
Organism:
Homo sapiens (Human)
Description:
O14672
Residue:
748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Inhibitor
Name:
BDBM50301103
Synonyms:
(2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | CHEMBL569166
Type:
Small organic molecule
Emp. Form.:
C24H32N4O4
Mol. Mass.:
440.5353
SMILES:
ONC(=O)[C@H]1CC(CC(=O)N2CCCC2)CN[C@@H]1C(=O)N1CCC(=CC1)c1ccccc1 |r,c:25|