Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50108653
Substrate
n/a
Meas. Tech.
ChEMBL_599822 (CHEMBL1042781)
Ki
1.3±n/a nM
Citation
 Jasper, A; Schepmann, D; Lehmkuhl, K; Vela, JM; Buschmann, H; Holenz, J; Wünsch, B Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety. Eur J Med Chem 44:4306-14 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50108653
Synonyms:
1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)] | 1'-benzyl-3-methoxyspiro[isochroman-1,4'-piperidine] | CHEMBL141209
Type:
Small organic molecule
Emp. Form.:
C21H25NO2
Mol. Mass.:
323.4287
SMILES:
COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Structure:
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