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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM17448
Substrate
n/a
Meas. Tech.
ChEMBL_595173 (CHEMBL1040015)
IC50
5000±n/a nM
Citation
 Röhrig, UF; Awad, L; Grosdidier, A; Larrieu, P; Stroobant, V; Colau, D; Cerundolo, V; Simpson, AJ; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem 53:1172-89 (2010) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase
Type:
PROTEIN
Mol. Mass.:
45639.39
Organism:
Mus musculus
Description:
ChEMBL_1452149
Residue:
407
Sequence:
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
  
Inhibitor
Name:
BDBM17448
Synonyms:
1,2,3-triazole analogue, 4 | 5-phenyl-1H-1,2,3-triazole
Type:
Small organic molecule
Emp. Form.:
C8H7N3
Mol. Mass.:
145.1613
SMILES:
c1[nH]nnc1-c1ccccc1
Structure:
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