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TargetAGTR1
LigandBDBM50303977
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595237
Ki 2226±n/a nM
Citation Mizuno, CSChittiboyina, AGShah, FHPatny, AKurtz, TWPershadsingh, HASpeth, RCKaramyan, VTCarvalho, PBAvery, MA Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome. J Med Chem53:1076-85 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
AGTR1
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:ANGIOTENSIN AT1 | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50303977
NameBDBM50303977
Synonyms:3-(4-(2-(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)ethoxy)-phenyl)-2-methyl-2-phenoxypropanoic acid | CHEMBL572276
TypeSmall organic molecule
Emp. Form.C37H38N4O4
Mol. Mass.602.722
SMILESCCCc1nc2c(C)cc(cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(O)=O)cc1)-c1nc2ccccc2n1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a