Target
Type-1 angiotensin II receptor A
Ligand
BDBM50303985
Substrate
n/a
Meas. Tech.
ChEMBL_595237 (CHEMBL1043589)
Ki
>10000±n/a nM
Citation
 Mizuno, CSChittiboyina, AGShah, FHPatny, AKurtz, TWPershadsingh, HASpeth, RCKaramyan, VTCarvalho, PBAvery, MA Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome. J Med Chem 53:1076-85 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50303985
Synonyms:
CHEMBL567269 | Ethyl 2,2-Dimethyl-3-(4-(2-(4-methyl-2-propyl-1H-benzo[d]-imidazol-1-yl)ethoxy)-phenyl)pro-panoate
Type:
Small organic molecule
Emp. Form.:
C26H34N2O3
Mol. Mass.:
422.5598
SMILES:
CCCc1nc2c(C)cccc2n1CCOc1ccc(CC(C)(C)C(=O)OCC)cc1
Structure:
Search PDB for entries with ligand similarity: