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Target
Adenosine receptor A2a
Ligand
BDBM50079652
Substrate
n/a
Meas. Tech.
ChEMBL_613367 (CHEMBL1068174)
IC50
1180±n/a nM
Citation
 Scheiff, AB; Yerande, SG; El-Tayeb, A; Li, W; Inamdar, GS; Vasu, KK; Sudarsanam, V; Müller, CE 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem 18:2195-203 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_CAVPO | ADENOSINE A2 | ADORA2A | Adenosine A2a receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44955.08
Organism:
GUINEA PIG
Description:
ADENOSINE A2 0 GUINEA PIG::P46616
Residue:
409
Sequence:
MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLRYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSQPKGDKNHSESCDEGQVTCLFEDVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECDHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGTSARASAAHSPEGEQVSLRLNGHPPGVWANGSALRPEQRPNGYVLGLVSGRSAQRSHGDASLSDVELLSHEHKGTCPESPSLEDPPAHGGAGVS
  
Inhibitor
Name:
BDBM50079652
Synonyms:
(E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone | (R)-1-(2-(2-hydroxyethyl)piperidin-1-yl)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 1-[2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone | CHEMBL440115 | FK-453
Type:
Small organic molecule
Emp. Form.:
C23H25N3O2
Mol. Mass.:
375.4635
SMILES:
OCC[C@H]1CCCCN1C(=O)\C=C\c1c(nn2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: