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Target
Melatonin receptor type 1A
Ligand
BDBM50316706
Substrate
n/a
Meas. Tech.
ChEMBL_632475 (CHEMBL1108339)
EC50
1.9±n/a nM
Citation
 Mésangeau, C; Pérès, B; Descamps-François, C; Chavatte, P; Audinot, V; Coumailleau, S; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Caignard, DH; Berthelot, P; Yous, S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem 18:3426-36 (2010) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50316706
Synonyms:
CHEMBL1097497 | N-[2-(7-{4-[3-(2-Acetylaminoethyl)benzo[b]thiophen-5-yloxy]butoxy}naphthalen-1-yl)ethyl]acetamide
Type:
Small organic molecule
Emp. Form.:
C30H34N2O4S
Mol. Mass.:
518.667
SMILES:
CC(=O)NCCc1csc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12
Structure:
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