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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM50199178
Substrate
n/a
Meas. Tech.
ChEMBL_639015 (CHEMBL1166153)
Temperature
298.15±n/a K
Ki
0.0090±n/a nM
Comments
extracted
Citation
 Meza-Avina, ME; Wei, L; Liu, Y; Poduch, E; Bello, AM; Mishra, RK; Pai, EF; Kotra, LP Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg Med Chem 18:4032-41 (2010) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
Orotidine phosphate decarboxylase | PYRF_YEAST | URA3
Type:
PROTEIN
Mol. Mass.:
29241.18
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_639015
Residue:
267
Sequence:
MSKATYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELLELVEALGPKICLLKTHVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQYSAGVYRIAEWADITNAHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELSCKGSLATGEYTKGTVDIAKSDKDFVIGFIAQRDMGGRDEGYDWLIMTPGVGLDDKGDALGQQYRTVDDVVSTGSDIIIVGRGLFAKGRDAKVEGERYRKAGWEAYLRRCGQQN
  
Inhibitor
Name:
BDBM50199178
Synonyms:
1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5'-monophosphate | 3,4-dihydroxy-5-(6-oxido-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphate | 6-HYDROXYURIDINE-5'-PHOSPHATE | 6-hydroxy-UMP | CHEMBL383923
Type:
Small organic molecule
Emp. Form.:
C9H13N2O10P
Mol. Mass.:
340.1807
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r|
Structure:
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