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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50321922
Substrate
n/a
Meas. Tech.
ChEMBL_642265 (CHEMBL1177145)
IC50
8600±n/a nM
Citation
 Moreno-Clavijo, E; Carmona, AT; Moreno-Vargas, AJ; Rodríguez-Carvajal, MA; Robina, I Synthesis and inhibitory activities of novel C-3 substituted azafagomines: a new type of selective inhibitors ofa-L-fucosidases. Bioorg Med Chem 18:4648-60 (2011) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase 1 | FUCA1 | FUCO_BOVIN
Type:
PROTEIN
Mol. Mass.:
54093.12
Organism:
Bos taurus
Description:
ChEMBL_335897
Residue:
468
Sequence:
MRSWVVGARLLLLLQLVLVLGAVRLPPCTDPRHCTDPPRYTPDWPSLDSRPLPAWFDEAKFGVFVHWGVFSVPAWGSEWFWWHWQGEKLPQYESFMKENYPPDFSYADFGPRFTARFFNPDSWADLFKAAGAKYVVLTTKHHEGYTNWPSPVSWNWNSKDVGPHRDLVGELGTAIRKRNIRYGLYHSLLEWFHPLYLRDKKNGFKTQYFVNAKTMPELYDLVNRYKPDLIWSDGEWECPDTYWNSTDFLAWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCKDKFQPETLPDHKWEMCTSIDQRSWGYRRDMEMADITNESTIISELVQTVSLGGNYLLNVGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQSEKNSVWYTSKGLAVYAILLHWPEYGILSLISPIATSTTKVTMLGIQKDLKWSLNPSGKGLLVFLPQLPPAALPTEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50321922
Synonyms:
(3S,4S,5R,6S)-3-(p-Phenylbenzoylaminomethyl)-6-methylhexahydropyridazine-4,5-diol hydrochloride | CHEMBL1173832
Type:
Small organic molecule
Emp. Form.:
C19H23N3O3
Mol. Mass.:
341.4042
SMILES:
C[C@@H]1NN[C@@H](CNC(=O)c2ccc(cc2)-c2ccccc2)[C@H](O)[C@@H]1O |r|
Structure:
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