Target
Mitogen-activated protein kinase 14
Ligand
BDBM50323648
Substrate
n/a
Meas. Tech.
ChEMBL_645062 (CHEMBL1211568)
IC50
310±n/a nM
Citation
 Montalban, AGBoman, EChang, CDCeide, SCDahl, RDalesandro, DDelaet, NGErb, EErnst, JTGibbs, AKahl, JKessler, LKucharski, JLum, CLundström, JMiller, SNakanishi, HRoberts, ESaiah, ESullivan, RUrban, JWang, ZLarson, CJ Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site. Bioorg Med Chem Lett 20:4819-24 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50323648
Synonyms:
CHEMBL1209755 | N-(3-tert-butylphenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide
Type:
Small organic molecule
Emp. Form.:
C28H32N2O4
Mol. Mass.:
460.5647
SMILES:
CC(C)(C)c1cccc(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: