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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50323659
Substrate
n/a
Meas. Tech.
ChEMBL_645062 (CHEMBL1211568)
IC50
1±n/a nM
Citation
 Montalban, AG; Boman, E; Chang, CD; Ceide, SC; Dahl, R; Dalesandro, D; Delaet, NG; Erb, E; Ernst, JT; Gibbs, A; Kahl, J; Kessler, L; Kucharski, J; Lum, C; Lundström, J; Miller, S; Nakanishi, H; Roberts, E; Saiah, E; Sullivan, R; Urban, J; Wang, Z; Larson, CJ Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site. Bioorg Med Chem Lett 20:4819-24 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50323659
Synonyms:
CHEMBL1208890 | N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phenyl)-2-oxo-2-(4-(pyrimidin-4-ylamino)naphthalen-1-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C28H29N5O5S
Mol. Mass.:
547.625
SMILES:
COc1c(NC(=O)C(=O)c2ccc(Nc3ccncn3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: