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TargetCysteinyl leukotriene receptor
LigandBDBM50323902
Substrate/Competitorn/a
Meas. Tech.ChEMBL_647615
EC50 1300±n/a nM
Citation Dong, XWang, LHuang, XLiu, TWei, EDu, LYang, BHu, Y Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem18:5519-27 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor
Name:Cysteinyl leukotriene receptor
Synonyms:CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38565.16
Organism:HUMAN
Description:Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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BDBM50323902
NameBDBM50323902
Synonyms:(E)-2-(2-(3-(4-(4-(4-Chlorophenoxy)butoxy)phenyl)acryloyl)-5-fluorophenoxy)acetic acid | CHEMBL1213847
TypeSmall organic molecule
Emp. Form.C27H24ClFO6
Mol. Mass.498.927
SMILESOC(=O)COc1ccc(F)cc1C(=O)\C=C\c1ccc(OCCCCOc2ccc(Cl)cc2)cc1
Structure
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