Reaction Details Report a problem with these data
Target
Acidic mammalian chitinase
Ligand
BDBM50027028
Substrate
n/a
Meas. Tech.
ChEMBL_649683 (CHEMBL1219381)
Kd
141000±n/a nM
Citation
 Cole, DC; Olland, AM; Jacob, J; Brooks, J; Bursavich, MG; Czerwinski, R; DeClercq, C; Johnson, M; Joseph-McCarthy, D; Ellingboe, JW; Lin, L; Nowak, P; Presman, E; Strand, J; Tam, A; Williams, CM; Yao, S; Tsao, DH; Fitz, LJ Identification and characterization of acidic mammalian chitinase inhibitors. J Med Chem 53:6122-8 (2010) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50027028
Synonyms:
2-(piperazin-1-yl)nicotinamide | 2-Piperazin-1-yl-nicotinamide | CHEMBL47688
Type:
Small organic molecule
Emp. Form.:
C10H14N4O
Mol. Mass.:
206.2444
SMILES:
NC(=O)c1cccnc1N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: