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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50325552
Substrate
n/a
Meas. Tech.
ChEMBL_652246 (CHEMBL1225449)
IC50
13000±n/a nM
Citation
 Matsuno, K; Takai, K; Isaka, Y; Unno, Y; Sato, M; Takikawa, O; Asai, A S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett 20:5126-9 (2010) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50325552
Synonyms:
CHEMBL1224313 | S-(4-Fluorobenzyl)isothiourea hydrochloride
Type:
Small organic molecule
Emp. Form.:
C8H9FN2S
Mol. Mass.:
184.234
SMILES:
NC(=N)SCc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: