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Target
Polycystin-2
Ligand
BDBM50336958
Substrate
n/a
Meas. Tech.
ChEMBL_718966 (CHEMBL1681588)
IC50
50±n/a nM
Citation
 Bravo-Altamirano, K; George, KM; Frantz, MC; Lavalle, CR; Tandon, M; Leimgruber, S; Sharlow, ER; Lazo, JS; Wang, QJ; Wipf, P Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. ACS Med Chem Lett 2:154-159 (2012) [PubMed]  Article 
Target
Name:
Polycystin-2
Synonyms:
PKD2 | PKD2_HUMAN | TRPP2
Type:
PROTEIN
Mol. Mass.:
109676.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_886731
Residue:
968
Sequence:
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
  
Inhibitor
Name:
BDBM50336958
Synonyms:
2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thiopheno[3,2-d]pyrimidin-6-one | CHEMBL1672575
Type:
Small organic molecule
Emp. Form.:
C10H9N3O2S2
Mol. Mass.:
267.327
SMILES:
COc1ncc2sc3c(SCCNC3=O)c2n1
Structure:
Search PDB for entries with ligand similarity: